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However, these are test-tube and animal studies, so they can only suggest what might work in people. More studies in humans are needed before conclusions can be made. A study of 16 people undergoing chemotherapy found that a one-to-one combination of CBD and THC administered via mouth spray reduced chemotherapy-related nausea and vomiting better than standard treatment alone . CBD may also help reduce chemotherapy-induced nausea and vomiting, which are among the most common chemotherapy-related side effects for those with cancer .

Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract . CBD has also shown antidepressant-like effects in several animal studies .

The placebo, a 150-mg dose of CBD, and a 600-mg dose of CBD had little to no effect on anxiety . In one Brazilian study, 57 men received either oral CBD or a placebo 90 minutes before they underwent a simulated public speaking test.

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The researchers found that a 300-mg dose of CBD was the most effective at significantly reducing anxiety during the test. According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth . Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being. An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis. Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.

One study found that Sativex reduced spasms in 75% of 276 people with multiple sclerosis who were experiencing muscle spasticity that was resistant to medications . Sativex, an oral spray consisting of CBD and THC, has been proven to be a safe and effective way to reduce muscle spasticity in people with multiple sclerosis.

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For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation . Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters .

  • Some of our regular CBD consumers have reported an awakening effect after using the product while others have said they experience a heightened sense of calm.
  • THC is only present in trace amounts, while CBD dominates the plant’s makeup.
  • Cannabidiol is just one of over 85 cannabinoids presently identified in the cannabis plant.
  • CBD oil made from hemp is non-intoxicating and will not cause any euphoric effects, but how using CBD oil makes you feel can vary from person to person.
  • This CBD oil allows users to experience the balancing effects of CBD, without the psychoactive intoxication of THC.
  • Others have shared that they don’t notice any sensations immediately after using CBD oil, but that with regular use the effects of CBD oil are apparent in how they feel each day.

High blood pressure is linked to higher risks of a number of health conditions, including stroke, heart attack and metabolic syndrome . Recent research has linked CBD with several benefits for the heart and circulatory system, including the ability to lower high blood pressure. For example, several studies have shown that treatment with CBD improved quality of life and sleep quality for people with Parkinson’s disease . However, it’s important to note that some people in both these studies experienced adverse reactions associated with CBD treatment, such as convulsions, fever and fatigue. One more study found that CBD oil significantly reduced seizure activity in children with Dravet syndrome, a complex childhood epilepsy disorder, compared to a placebo .

Researchers believe that CBD’s ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders. Though these results are promising, human studies exploring the effects of CBD on acne are needed. One test-tube study found that CBD oil prevented sebaceous gland cells from secreting excessive sebum, exerted anti-inflammatory actions and prevented the activation of “pro-acne” agents like inflammatory cytokines . It is thought to be caused by a number of factors, including genetics, bacteria, underlying inflammation and the overproduction of sebum, an oily secretion made by sebaceous glands in the skin .